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Suprachoroidal drug delivery: A novel approach in treating wet age-related macular degeneration (AMD)

DOI: 10.5677/2012-1-13

Submitted by: Gabor B. Scharioth, MD

Intravitreal injection is the most popular of the current approaches for delivering drugs to the back of the eye. This video describes a new technique for drug administration to the back of the eye, namely to the suprachoroidal space via a microcatheter. The catheter is introduced under the choroid using a transscleral approach in the temporal superior quadrant. The exact position of the microcatheter is visualized by a blinking light source at its tip. When the correct position at the posterior pole is achieved, liquid drugs, e. g. bevacizumab, can be administered to the suprachoroidal space, directly adjacent to the choroidal neovascular membrane. Direct drug delivery is possible to the back of the eye using this technique.

Keywords: age-related macular degeneration, AMD, drug delivery, choroid, macula

References:
1) Tetz M, Rizzo S, Augustin AJ. Safety of Submacular Suprachoroidal Drug Administration via a Microcatheter: Retrospective Analysis of European Treatment Results. Ophthalmologica. 2012 Feb 21. [Epub ahead of print]
2) Olsen TW, Feng X, Wabner K, Csaky K, Pambuccian S, Cameron JD. Pharmacokinetics of pars plana intravitreal injections versus microcannula suprachoroidal injections of bevacizumab in a porcine model. Invest Ophthalmol Vis Sci. 2011;52(7):4749-56
3) Patel SR, Lin AS, Edelhauser HF, Prausnitz MR. Suprachoroidal drug delivery to the back of the eye using hollow microneedles. Pharm Res. 2011;28(1):166-76
4) Puchta J, Mirshahi A. 23-gauge vitrectomy and subretinal rTPA injection for submacular hemorrhage. Video Journal of Vitreoretinal Surgery. 2010. DOI: 10.5677/2010-1-2
5) Scharioth GB, Raak P, Pavlidis M. Suprachoroidal bevacizumab delivery for neovascular AMD treatment. Retinal Physician. 2011;April:56-9

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Suprachoroidal drug delivery: A novel approach in treating wet age-related macular degeneration (AMD)

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Institution: Aurelios Eye Center, Recklinghausen, Germany
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